Post-doctoral Position in Mucosal Immunology/Inflammatory Bowel Disease

Employer
Weill Cornell Medicine
Location
New York City, New York (US)
Salary
Depends on Experience
Posted
October 30 2017
Organization Type
Academia

Post-doctoral Position in Mucosal Immunology/Inflammatory Bowel Disease

The laboratory of Dr. Julie Magarian Blander at Weill Cornell is seeking post-doctoral candidates to study the mechanisms of cellular stress, autophagy and death within the intestinal epithelium, and the impact of these processes on intestinal microbiota and homeostasis/inflammation. Our recent publications on this topic include:

https://doi.org/10.1016/j.cell.2017.09.034

http://www.nature.com/ni/journal/v17/n9/full/ni.3512.html

http://www.nature.com/nature/journal/v539/n7630/full/nature20138.html

https://www.nature.com/ni/journal/v18/n8/full/ni.3780.html

http://onlinelibrary.wiley.com/doi/10.1111/imr.12537/abstract

http://onlinelibrary.wiley.com/doi/10.1111/febs.13771/abstract


Intestinal epithelial damage is characteristic of inflammatory bowel disease (IBD). This damage manifests in a notable increase in programmed cell death of intestinal epithelial cells (IEC) in patients with IBD. The most obvious effect of IEC death is disruption of the epithelial barrier and consequent loss of all its protective and antimicrobial activities leading to dysbiosis. The successful candidate will work on areas addressing critical gaps in the understanding of IBD pathogenesis:

  1. Is excessive IEC death causative or secondary to the chronic inflammation characteristic of IBD?
  2. Are there microbe(s) that initiate, aggravate or perpetuate IBD?
  3. What is the critical determinant of the therapeutic success of antibodies to TNF-a, a major proinflammatory cytokine in IBD that triggers IEC shedding and death?


A PhD or equivalent in Immunology is required. Relevant backgrounds include work with human IBD tissues, animal models, mucosal immunology, innate immune signaling, autophagy and cell death, T cell and myeloid cell biology. Technical expertise in the following is highly desirable: multi-parameter flow cytometry, protein and/or nucleic acid biochemistry, CRISPR/Cas-mediated genome engineering, mouse genetics, confocal/high resolution fluorescence microscopy, intestinal organoid cultures.]

If you are interested, please send a cover letter describing your research background, interests and career goals, as well as a CV and contact information of three references to Dr. Blander (jmblander@med.cornell.edu).

Weill Cornell Medicine is an employer and educator recognized for valuing AA/EOE/M/F/Protected Veterans, and Individuals with Disabilities.

PI99967883

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