Director, Translational Pharmacology, Neuroscience

Rahway, NJ, US
October 26 2017
Organization Type
Requisition ID: CLI006719

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

Translational Pharmacology at Merck Research Labs is responsiblefor early clinical development of novel therapeutics, working in closecollaboration with Discovery Sciences and late stage Clinical Research. We areseeking highly qualified individuals with expertise in Neurology orPsychiatry. 


Translational Pharmacology is specifically responsible for:


  • Contributingto the identification of novel targets by partnering with discoveryresearch teams to bring a clinical perspective into the earliest stages oftarget identification and validation, and executing clinical studies thatcan be bridged into full development
  • Developmentof biomarker strategies through cross-functional teams that provideline-of-sight from First-in-Human studies through clinical Proof-of-Concept.  This may include Experimental Medicinestudies to establish and/or validate biomarker platforms.
  • Developmentand execution of the early clinical development strategy for novel therapyprograms from Preclinical Candidate approval through clinicalProof-of-Concept (Phase 2a)
  • Developmentand execution of clinical pharmacology strategies for late stagedevelopment programs from Proof-of-Concept (Phase 2a) through worldwidemarketing application 
  • Success depends on the integrity, knowledge, imagination,creativity, skill, diversity and teamwork of the people in the group. To thisend, we strive to create an environment of mutual respect, encouragement andteamwork. As part of the global team, you will collaborate with talented anddedicated colleagues in Translational Pharmacology, as well as DiscoverySciences and late stage Clinical Research while developing and expanding yourcareer.


    Individuals will report directly the Translational Pharmacology NeuroscienceLead.


    Primary responsibilities will include the following:


  • Key memberof early development teams, providing leadership in designing andexecuting early clinical development strategy 
  • Developmentand execution of early clinical strategy for novel therapeutics includingauthoring initial clinical and biomarker plans for Lead Optimizationprograms, early clinical development plans for Preclinical Candidatemolecules, and clinical pharmacology studies for programs in Phases Ithrough IV of development.
  • Developmentand execution of studies to validate clinical platforms utilizingestablished and novel biomarkers to demonstrate biological activity inhumans.
  • Provideclinical expertise for identification and validation of novel targets  including the design of preclinical and/orclinical pharmacology experiments to validate targets and/orpathways 
  • Safe andtimely execution of Phase I studies; close collaboration with internal andexternal clinical study support staff and scientists (including discoveryresearch, biostatistics, drug metabolism, modeling and simulation,regulatory affairs, and global clinical trials operations) 
  • Provideclinical pharmacology support for programs through the worldwide marketingapplication filing including supportive registration documents andpresentations 
  • Provideclear, timely communication and interpretation of study results totherapeutic area governance, functional area experts and developmentreview committees. 
  • Contributeto assessment of internal and external opportunities identified byBusiness Development and Licensing 
  • Interfacebroadly with key functions including Discovery Sciences, PreclinicalPharmacology, Pharmaceutical Sciences, Toxicology, TranslationalBiomarkers, Drug Metabolism/Modeling & Simulation, Regulatory Affairs,late stage Clinical Research 
  • Qualifications


    • MD or MD/PhD OR PhD with  at least 10 years of drug development experience to include preclinical pharmacology, biomarker validation and development, and team management


    • Proven track record in clinical medicine or clinical research, and background in neuroscience research.
    • Demonstrated record of scientific scholarship and achievement in neuroscience research, translational medicine and/or early drug development.
    • Strong interpersonal, writing and presentation skills, as well as the ability to function in a team environment are essential.


    • Prior specific experience in clinical research and prior publication is desirable but not necessary; preferably with experience in the area of basic, translational neuroscience research and/or early clinical development
    • Board Certification or Eligibility in Neurology or Psychiatry preferred

    Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 


    If you need an accommodation for the application process please email us at


    Search Firm Representatives Please Read Carefully: 

    Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.


    For more information about personal rights under Equal Employment Opportunity, visit:


                EEOC Poster

                EEOC GINA Supplement 

    Job: Clinical Research (M.D.)
    Other Locations:
    Employee Status: Regular
    Travel: Yes, 20 % of the Time
    Number of Openings:
    Shift (if applicable):
    Hazardous Materials:
    Company Trade Name: Merck

    Similar jobs

    Similar jobs