Cellular Bioenergetics in Neurodegenerative Diseases: A system-based pathway and target analysis ...

Università degli Studi di Padova - Dipartimento di Scienze Biomediche
October 12 2017
Position Type
Full Time
Organization Type

The project is based on a systems-based target analysis to determine the contribution of mitochondria and cell bioenergetics to disease progression in three common neurodegenerative disorders: Parkinson's disease (PD), Alzheimer's disease (AD) and Huntington's disease (HD). Specific aims will be: i) elucidate common and distinct disease mechanisms in AD, PD and HD focusing on pathways regulating mitochondrial functions and cell bioenergetics; ii) employ computational modelling frameworks and a HTS approach to identify drug candidates and therapeutic targets

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