Study of the role of NFKB1 and NFKB2 in the homeostasis of the human immune system: primary immun...

Università degli Studi di Brescia
October 12 2017
Position Type
Full Time
Organization Type

The Nf-kB pathway plays an essential role in numerous biological processes. Recently, mutations in components of the Nf-kB pathway such as NEMO, NIK, IKK, NFKB1 and NFKB2 have been shown to cause primary immunodeficiency. Regarding the latter two components, our group has shown that both NFKB1 and NFKB2 regulate important effector functions of human Natural Killer (NK) cells. In addition, our group recently showed that NFKB1 regulates early (bone marrow) and late (periphery) B cell differentiation. The objective of this project is to study the role of NFKB1 and NFKB2 in the maturation and effector function of other cell types of the human immune system such as neutrophils, regulatory B and T cells, and dendritic cells, using as a model the patients mutated in one of these two Nf-kB components. Our results will then be further validated by the use of specific Nf-kB inhibitors.

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