Associate Principal Scientist, Medicinal Chemistry Job

South San Francisco, CA, US
October 12 2017
Organization Type
Requisition ID: RES001944

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research.  Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck’s world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck’s powerful world-class network of drug and vaccine discovery.
At Merck, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Merck Research Labs South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

Merck is currently seeking exceptional chemists for positions within the Discovery Chemistry Department located at our South San Francisco, CA site. The successful candidate will join multidisciplinary, highly collaborative discovery teams leveraging innovative synthetic chemistry and rigorous analysis of diverse data sets to invent novel medicines. Specific responsibilities will include:

  • Act as a leader in the laboratory, driving program and chemistry strategy and execution

  • Provide scientific mentoring and technical training of team members

  • Develop and utilize innovative synthetic and medicinal chemistry problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships

  • Design, synthesize, purify and characterize drug candidates in target validation, hit-to-lead and lead optimization projects

  • Help identify and validate new targets, which may include collaborative engagement with the external scientific community and leadership of early drug discovery projects

  • Establish a substantial external scientific presence including authoring significant scientific publications and presentations





  • Required: Ph.D. in Chemistry

Required Experience:

  • Minimum of (3) years Pharmaceutical Industry experience in Drug Discovery

  • Strong interpersonal, collaboration and communication skills 

  • Rigorous scientific thinking and a proven track record of driving the advancement of Drug Discovery programs.

The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us at
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.  Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for us all.


Job: Research Science
Other Locations:
Employee Status: Regular
Number of Openings:
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck

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