Senior Scientist, Cellular Pharmacology Job

Boston, MA, US
October 10 2017
Organization Type
Senior Scientist, Cellular Pharmacology:PHA001403


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

The In Vitro Pharmacology department is seeking a highly motivated and technically skilled in-vitro Senior Scientist to join the Cellular Pharmacology group in Boston. The primary responsibilities will include the design and implementation of various in vitro cellular platforms, primarily developing 3D and organoid–based assays for precision medicine studies. In addition the successful candidate will be involved in execution of high throughput compound and biologics screens in support of internal drug discovery programs. The candidate is expected to work both independently and collaboratively with colleagues in pharmacology and across other departments.

The specific responsibilities of the candidate include but are not limited to:

- Independently design and implement various cellular in vitro assays using a wide range of methodologies, including 3D and organoid cultures.

- Execute semi- and fully automated high throughput compound and biologics screens in support of internal drug discovery programs.

- Develop and execute experimental strategies to define biomarkers, mechanisms of action and resistance of therapeutic agents of interest.

- Properly document and report the experimental findings and provide scientific contribution to research projects/programs in multiple disease areas

- Work closely with members within department and across functional teams in support of research projects/programs at different stages.



- A Master’s degree in Biology or related disciple with a minimum of 5 years relevant industry or academic experience or PhD (preferred) in Biological Sciences or related discipline with a minimum of 2 years post-doctoral experience.


- Extensive job related laboratory research with 3D, Organoid and iPSC Tissue Culture methodologies in academic or industrial setting

- Experience with multi-parametric flow cytometry and Imaging platforms.

- Hands-on assay development and troubleshooting skills and proficiency with different high throughput screen formats.

- Solid data analytical and problem solving skills and proficiency in standard scientific software used for data analysis.

- Excellent oral and written communication skills, including preparation of study reports, presentations and manuscripts for publication in peer reviewed scientific journals.

- Demonstrated ability to function and communicate effectively in a multi-disciplinary environment and thrive in a team environment.


- Research and drug discovery experience in immunology, oncology and immuno-oncology.

- Experience with DNA and RNA sequencing

- Experience with operating robotic equipment and familiarity with the latest HTS detection technologies.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.

If you need an accommodation for the application process please email us at

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Primary Location: NA-US-MA-Boston

Job Type: Full Time

Employee Status: Regular

Travel: No

Number of Openings: 1

Hazardous Materials: Biohazards

Alternative Work Arrangements Available: Not Available

Relocation Provided: Domestic (within country)

Company Trade Name:Merck

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