Senior Scientist - Immunology Job

Boston, MA, US
October 09 2017
Organization Type
Senior Scientist - Immunology:BIO004963


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

The Discovery organization seeks an outstanding candidate to join the Therapeutic Area – Autoimmune and Inflammation Group. This Senior Scientist role will focus on designing and performing experiments using functional in vitro and ex vivo cell-based immunoassays to advance drug discovery research programs from target validation through to lead identification. Broad expertise in immunobiology is required for this role, with preference given to candidates with demonstrated experience in immunology drug discovery and development. The successful candidate will have deep scientific curiosity, excellent oral and written communication skills, the ability to function independently and as part of a team, and be able to work on multiple projects simultaneously. With limited supervision, the role includes developing and optimizing methodologies and assays as well as planning, designing, and executing experiments using good scientific judgment. The position is a hands-on, laboratory based role with no direct reports (individual contributor), but s/he may act as a scientific mentor and coordinate the activities of junior research scientists in support of project objectives.



- Ph.D. in immunology, cell biology, pharmacology, or related field with relevant post-doctoral training; 2+ years’ experience in the pharmaceutical/biotech industry is preferred (highly qualified candidates with a Master’s degree and 6+ years’ industry experience will also be considered).
- S/he should provide clear evidence of scientific productivity, as evidenced by peer-reviewed publications in top-tier journals and/or by demonstrable achievements in an industrial environment.


- Solid training and background in cellular immunology, preferably with area expertise in autoimmunity, immuno-oncology, or infectious disease (including familiarity with associated rodent pre-clinical models).
- Ability to independently design, perform and interpret data derived from cellular immune function assays (e.g., differentiation, proliferation, cytotoxicity, cytokine production).
- Broad expertise and familiarity with assays and technologies commonly used to assess immune endpoints (e.g., MLR, antigen-specific T/APC cultures; ELISA/ELISPOT, Mesoscale, Luminex; qPCR, NanoString); solid cell line and primary immune cell tissue culture skills.
- Experience in multi-parameter flow (FACS) and/or mass (CyTOF) cytometry and proficiency in subsequent downstream data analysis using programs such as FlowJo, FACSDiva, and Cytobank; experience with tissue processing and cell isolation technologies (e.g., Ficoll separation, Miltenyi AutoMACS, FACS sorting).
- Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds.
- Ability to contribute at a scientific and strategic level to drug discovery research programs in immunology, including proposal and identification/validation of novel targets.
- S/he should be a strong team player with excellent oral and written communication skills and a demonstrated ability to work independently to design and execute experiments, organize and interpret data, troubleshoot, and suggest next steps.


- Demonstrated project lead experience in an academic or industrial research setting.
- Demonstrated experience mentoring and training junior scientists.
- Experience with in vivo immune-mechanistic or autoimmune/cancer/infection rodent models and their application towards pharmacological assessment of drug efficacy and mode-of-action; ability to perform (or willingness to learn) basic mouse handling and manipulation techniques (injections, post-mortem tissue collection).
- Demonstrable experience with in vitro pharmacology assays involving large or small molecule drugs, e.g., experimental design and replication, titration and potency value determination, etc.
- Cell manipulation and engineering towards assay development and target validation (e.g., plasmid/RNAi delivery, CRISPR/Cas9 genomic editing, clonal selection and optimization of reporter cell lines).
- Experience directing and coordinating work with external academic/industry partners or with contract research organizations.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.

If you need an accommodation for the application process please email us at

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Primary Location: NA-US-MA-Boston

Job Type: Full Time

Employee Status: Regular

Travel: Yes, 10 % of the Time

Number of Openings: 1

Hazardous Materials: Radioactive isotopes, chemicals and Merck internal cmpds, primary human blood

Company Trade Name:Merck

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