PhD Graduate Student Positions on Antimicrobial Drug Discovery
PhD graduate research positions on NSF, NAS and NIH funded antimicrobial drug discovery projects at Purdue University are available with Dr. Mohamed Seleem’s group for Spring 2018. The group takes a multidisciplinary approach1-8, employing drug discovery, bacterial genetics, cell biology, molecular microbiology, structural biology, molecular diagnostics, drug delivery, nanoparticles, pharmacokinetic, and animal models.
Purdue University, located in West Lafayette, Indiana, USA, is an internationally recognized research and teaching institution renowned for its academic excellence, world-class faculty, and commitment to cultivating a diverse intellectual community. Purdue University is one of the leading universities for higher education and graduate programs in the world. Purdue ranks fourth among public institutions in the United States and Purdue's graduate programs have been ranked among the top 10 by U.S. News.
The assistantship provides monthly stipend and payment of tuition fees. We are looking for highly motivated candidates. Students with previous research experience or a Master’s degree are strongly encouraged to apply. TOEFL and GRE are required for application. Details of the requirements for the application process are available at the CPB Department website https://vet.purdue.edu/cpb/graduate-programs.php
Purdue University is an EOE/AA employer. All individuals, including minorities, women, individuals with disabilities, and veterans are encouraged to apply.
1- Pei, Y., Mohamed, M. F., Seleem, M. N. & Yeo, Y. Particle engineering for intracellular delivery of vancomycin to methicillin-resistant Staphylococcus aureus (MRSA)-infected macrophages. J Control Release, doi:10.1016/j.jconrel.2017.08.007 (2017).
2- Yin, X. et al. Rapid synthesis of bicyclic lactones via palladium-catalyzed aminocarbonylative lactonizations. Chem Commun 53, 7238-7241 (2017).
3- Mohammad, H. et al. Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci. J Med Chem 60, 2425-2438, (2017).
4- Karanja, C. W. et al. Stimulated Raman Imaging Reveals Aberrant Lipogenesis as a Metabolic Marker for Azole-Resistant Candida albicans. Anal Chem 89, 9822-9829, (2017).
5-Hagras, M. et al. Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA). J Med Chem 60, 4074-4085, (2017).
6- Brezden, A. et al. Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide. J Am Chem Soc 138, 10945-10949, (2016).
7-Abushahba, M. F., Mohammad, H. & Seleem, M. N. Targeting Multidrug-resistant Staphylococci with an anti-rpoA Peptide Nucleic Acid Conjugated to the HIV-1 TAT Cell Penetrating Peptide. Mol Ther Nucleic Acids 5, e339, (2016).
8- Seleem, M. A. et al. Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties. J Med Chem 59, 4900-4912, (2016).