2 PhD students Biotechnology and Safety

Wageningen University & Research
October 06 2017
Position Type
Full Time
Organization Type

Functie omschrijving:
Native genes from a crop species can be introduced through classical breeding or through novel breeding techniques. Novel breeding techniques have several decisive advantages over classical breeding, especially in crops with slow breeding progress. However, with the introduction of new technology, questions about safety arise and thus must be addressed.
In this project two PhD students will work together to study novel plant breeding techniques from a biotechnology and from a modelling of food safety angle.

PhD student Biotechnology:
You will design a new research approach to repair or re-shuffle inactive late blight resistance genes in potato using CRISPR-Cas technology to produce late blight resistant varieties. The resulting recombination events will be used for food safety research by the second PhD student, and for potential off-target effects elsewhere in the genome by yourselves. Bioinformatics pipelines will be developed to process whole genome sequencing data and will serve as a basis for novel safety assessment protocols. The candidate will work in the department of Plant Breeding of Wageningen University & Research, and there will be collaboration with the Biometris department( and the RIKILT Institute for Food Safety).

PhD student Modelling food safety:
You will design new statistical safety assessment methodology, as an alternative to current regulatory risk assessment procedures. You will apply multivariate statistical modelling for the assessment of the safety of novel potato varieties based on transcriptomics and metabolomics data. The methodology will be based on comparing broad-spectrum -omics measurements for the potato variety to be tested with measurements for classically bred varieties using new and optimized statistical methods. The candidate will work in the Biometris department of Wageningen University & Research, and there will be collaboration with the department of Plant Breeding and the RIKILT Institute for Food Safety.

This job comes from a partnership with Science Magazine and Euraxess