Novel electrophysiological measure of Multiple Sclerosis-associated inflammatory neurodegeneration
Axonal damage and loss are crucial determinants of irreversible disability in MS. Thus, retinal nerve fiber layer thinning and macular volume reduction measured by OCT are markers of retinal axonal damage and are assumed to reflect similar pathologic changes occurring in the brain, as a result of widespread neurodegenerative process. Therefore corresponding markers of spinal GM neurodegeneration and related disease progression are needed. Motor Unit Number Estimation (MUNE) is an excellent tool to track motor unit loss and this research suggests MUNE as a new potential measure of SC atrophy in MS patients. Therefore it could be promising to study MUNE in MS patients with and without spinal cord lesions; MUNE parameters changes in MS subtypes and in relation to clinical disability measures; correlation between MUNE and OCT measures of neurodegeneration; between MUNE serological and CSF inflammatory and neurodegenerative biomarkers as well as MRI-detected acute inflammatory status.
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