Caspase-8 in the modulation of tumor microenvironment in glioblastoma

Employer
UNIVERSITA' DEGLI STUDI DI ROMA TOR VERGATA - DIPARTIMENTO DI BIOLOGIA
Location
Italy
Posted
October 05 2017
Discipline
Other
Position Type
Full Time
Organization Type
Academia

The project aims to define a new function of Caspasi-8 as a modulator of the tumor micro-environment. Specifically, this research proposal has the following objectives: 1) Develop neurosphere culture models derived from human glioblsatomas to study in vitro and in vivo the ability of Caspase-8 to modulate tumorigenicity and cencer stem cells ; 2) develop in vitro and in vivo studies to evaluate how thegenetic and pharmacolocal regulation of Caspase-8 expression and phosphorylation may modulate tumor growth and tumor neoangiogenesis.Overall this study will evaluate the therapeutic potentiality of new molecular strategies h in glioblastoma.



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