Antiproliferative effects of adiponectin in lung cancer
Lung cancer is a major cause of death worldwide. There is need to identify appropriate and effective molecular markers in lung cancer to improve both prognosis and survival rate. In this context the role of adipose tissue Adipokines, such as Adiponectin (Acrp30 a protein hormone of 244 amino acids) is attracting growing interest.
Aim of Research
To determine the extent to which adiponectin system is implicated in Lung Cancer development and progression. The research will focus on the analysis serum samples from lung cancer patients for Acpr30 expression profile and HMW forms. In addition, it will be investigated the expression of AdipoRs and T cadherin in tissues from lung cancer both at mRNA and protein levels. Successively, it will be explored the actions of Acrp30 in vitro, using the human alveolar epithelial A549cell line taken as a model of lung cancer.
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