Role of adiponectin in severe/moderate COPD patients
Chronic Obstructive Pulmonary Disease (COPD) is a severe pulmonary disease characterized also by extrapulmonary manifestations including endothelial dysfunctions, cardiovascular disease (CVD), systemic inflammation, oxidative stress, and alterations in energy balance and body composition. Recently, an increase in adiponectin serum levels have been reported in COPD patients, suggesting a direct role of the adipocytokine in the disease. However, the biological role is far from being characterized.
Aim of Research
To determine the extent to which adiponectin system is implicated in CVD development in COPD and consequently whether adiponectin could represent a diagnostic and prognostic marker for both COPD and CVD disease. Adiponectin serum levels will be measured in COPD patients; in addition AdipoRs expression at mRNA and protein level will be assessed in lung tissues obtained from COPD undergoing thoracic surgery.
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