Platelet function in Antiphospholipid Syndrome

Employer
DIPARTIMENTO DI SCIENZE CARDIOLOGICHE, TORACICHE E VASCOLARI
Location
Italy
Posted
October 05 2017
Position Type
Full Time
Organization Type
Academia

Despite extensive research, the pathogenesis of antiphospholipid syndrome (APS) remains obscure in many aspects. However, it is widely accepted that thrombosis is the result of a hypercoagulable state caused by antibodies directed against β2-glycoprotein I (β2-GPI), a protein whose physiological role is unknown. Although underestimated, platelets may be involved in APS and its thrombotic manifestations, especially arterial, in several ways. Thrombocytopenia is the most relevant non-criteria manifestation of APS, possibly caused by direct binding of anti-β2-GPI antibodies or anti-β2-GPI-β2-GPI complexes. Aim of the study is the interaction of anti beta2GPI antibodies with platelets



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