Epigenetic regulation of plant reproductive development (FENG_J18DTP)
Sexual reproduction in flowering plants is carried out by highly specialised lines of cells, called the sexual lineages. A fundamental but unresolved question is how the reproductive function and fate are installed and maintained precisely in these cell lineages. Preliminary studies in the Feng Group suggest that an epigenetic pathway promotes sexual lineage development via controlling genic DNA methylation, thereby contributing to the shift of gene expression during transition from somatic to reproductive development. This PhD project aims to investigate the molecular mechanism by which the DNA methylation pathway regulates sexual lineage development in the model plant Arabidopsis, using a combination of genetics, molecular and cell biology, epigenetics and genomics. This work will demonstrate, for the first time, how an epigenetic pathway can be tailored in a specific lineage of cells to convey precise biological functions, laying a foundation for the study of epigenetic regulation of plant development.
Working at the interface of developmental biology and epigenetics, you will greatly benefit from the scientific trainings in both fields. This project involves state-of-the-art techniques of molecular biology, flow cytometry, microscopy, high-throughput sequencing, and bioinformatics (eg. dealing with epigenomic data). You will receive support from a multidisciplinary group, and be encouraged and funded to attend conferences. JIC has a world class PhD training programme, providing not only top infrastructure and academic environment for your research, but also a number of training courses on transferable skills such as project management, presentation and leadership skills to promote your all-around development and employability.
This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 9th, 10th or 11th January 2018.
The Norwich Biosciences Doctoral Training Partnership (NRPDTP) offers postgraduates the opportunity to undertake a 4 year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.
For further information and to apply, please visit our website: http://www.biodtp.norwichresearchpark.ac.uk
Full Studentships cover a stipend (RCUK rate: £14,553pa - 2017/8), research costs and tuition fees at UK/EU rate, and are available to UK and EU students who meet the UK residency requirements.
Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships, which when combined will equal a full studentship. To be eligible students must meet the EU residency requirements. Details on eligibility for funding on the BBSRC website: http://www.bbsrc.ac.uk/web/FILES/Guidelines/studentship_eligibility.pdf
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