Principal Research Associate, Rare Diseases

October 04 2017
Life Sciences, Biology
Organization Type
Principal Research Associate, Rare Diseases

Position Summary

We seek a talented, experienced and motivated Sr. Research Associate to assist in developing the preclinical data package to support advancement of Moderna's mRNA technology platform and pipeline. The successful candidate is an experienced hands-on cellular and molecular pharmacologist who will make significant contributions to the design and execution of preclinical in vitro and in vivo studies in the area of rare diseases.  He/she will support the preclinical in vitro and vivo pharmacology effort to validate the potential of novel mRNA therapeutics for the rare disease therapeutic area. The ability to effectively communicate with internal team members and external partners is required.


  • Develop all necessary in vitro/ex vivo assays to measure RNA levels, expressed protein levels, enzymatic activities and in-depth functionality of new therapeutics mRNAs
  • Execute in vivo preclinical studies using rodent models of rare diseases
  • Execute and troubleshoot standard protocols, adapt new protocols into practice with little assistance, and query literature to incorporate additional assays as needed
  • Independently execute experiments
  • Deliver rigorous results in aggressive timelines
  • Closely collaborate with other members within the research group and broadly with departments throughout the company
  • Analyze, interpret and present data to internal parties


  • BS with 5-8 years of experience or MS with 2-5 years of experience, preferably in a biotech setting with experience in drug discovery or translational research     
  • Hands-on experience with in vitro and ex vivo assays
  • Hands-on experience with cellular and molecular biology techniques
  • Hands-on experience with radioactive assays
  • Hands-on experience with enzymatic assays preferred
  • Hands-on experience with LCMS, GCMS and LC-MSMS preferred
  • Familiarity with disease biomarkers assessment preferred
  • Knowledge in rare disease rodent models preferred
  • Team player with a can-do attitude, effective problem-solving skills, scientific rigor, and strong work ethic


Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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