PhD position: Chromosome Dynamics and Meiosis

Employer
International PhD Programme “Dynamics of Gene Regulation, Epigenetics and DNA Damage Response”
Location
Germany
Posted
October 03 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

In the field of “Chromosome Dynamics and Meiosis” the research group of Prof. Peter Baumann offers the following PhD project:


The mechanism of meiosis in unisexual lizards 


By examining oocytes from parthenogenetic and closely related bisexual species we provided conclusive evidence for meiosis initiating with twice the number of chromosomes in unisexual females. By doubling the number of chromosomes prior to meiosis, the normal meiotic program produces diploid rather than haploid eggs.  We have also developed fluorescent in situ hybridization probes to distinguish between homologous chromosomes. These reagents enabled us to demonstrate that pairing and recombination occur between genetically identical chromosomes, not between homologs.  These important deviations from the normal meiotic program explain key features of the lizards' ability to reproduce clonally and to compete with bisexual species over many generations.  An incoming graduate student will now focus on two fundamental questions:


(i) How is homolog pairing blocked in parthenogenetic species?


(ii) What mechanism underlies the doubling of chromosomes prior to meiosis?


The successful candidate will be using a combination of ovarian tissue culture and advanced imaging techniques to answer these questions.  The approaches will be aided by reagents and computational tools generated in the laboratory that allow us to visualize chromosome dynamics in unprecedented detail. These results will inform subsequent experiments aimed at understanding the molecular events through which barriers to unisexuality are overcome in some species.


 


We offer


  • The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team

  • A stimulating, diverse and international research environment

  • Advanced training opportunities

  • A fully funded PhD position

 


Duration of stipend/salary: 3 years, with the possibility of extension


Starting date: 1 March 2018 or later


Deadline for registration (exclusively online via web form): 15 November 2017


 


For further questions and contact information please check our website:


www.imb.de/PhD/


 


Please apply exclusively via our online form at:


www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp/



This job comes from a partnership with Science Magazine and Euraxess