PhD position: Signalling by Polyubiquitin Chain Linkage

Employer
International PhD Programme “Dynamics of Gene Regulation, Epigenetics and DNA Damage Response”
Location
Germany
Posted
October 03 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

In the field of Signalling by Polyubiquitin Chain Linkage”, the research group of Prof. Helle Ulrich offers the following PhD project:


Analysing the significance of polyubiquitin chain linkage by means of tailor-made ubiquitin ligases

 


A PhD project is offered in the context of an EU-funded Innovative Training Network (“UbiCODE”), representing a consortium of 11 laboratories throughout Europe that will collaborate on elucidating the mechanisms and significance of polyubiquitin signalling in cellular pathways ranging from DNA repair and carcinogenesis to autophagy and bacterial infection. The proposed project aims at understanding the relevance of polyubiquitin chain linkage by means of a novel technology that, for the first time, allows the substrate- and linkage-selective ubiquitylation of any protein of interest in vitro or in living cells. We have designed a set of tailor-made ubiquitin ligases capable of attaching polyubiquitin chains of defined linkages to a given substrate protein fused to a small, matching specificity tag. In this manner, we are able to induce linkage-specific polyubiquitylation of desired proteins in cells, to directly manipulate the linkage of a polyubiquitin chain on a given substrate, to prepare large amounts of polyubiquitylated proteins for the identification of interaction partners and to target polyubiquitin chains to various sub-cellular compartments, such as chromatin or internal membranes. The PhD student will now explore the versatility of this technology by applying it to a series of biological pathways regulated by polyubiquitylation. Depending on the interests of the student, these could include chromatin-associated processes such as DNA damage repair and signalling, but also endocytosis and inflammatory signalling. In addition to the programme offered by the IPP, the PhD student will be able to participate in a series of events and practical courses dedicated to the ubiquitin system within the UbiCODE network.    


We offer


  • The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team

  • A stimulating, diverse and international research environment

  • Advanced training opportunities

  • A fully funded PhD position

Duration of stipend/salary: 3 years, with the possibility of extension


Starting date: 1 March 2018 or later


Deadline for registration (exclusively online via web form): 15 November 2017


 


For further questions and contact information please check our website:             


www.imb.de/PhD/


 


Please apply exclusively via our online form at:


www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp/


 



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