Role of HCAR2 receptor in diabetic retinopathy in a mouse model of experimental diabetes
In this study we will evaluate the possible role of the HCAR2 receptor in the retinopathy associated with diabetes. HCAR2 is a deorphanized receptor activated by beta-hydroxy butyrate (BHB), a ketone body which increased after prolonged starvation, ketogenic diet or diabetes. The experimental diabetes will be induced by injection of streptozotocin.
We will evaluate the retinopathy by focusing mainly on the role of the microglia cells that have been found to be hypertrophic in the early stage of the diabetic retinopathy. Hypertrophic microglia have been shown to express HCAR2. The pharmacological manipulation of the HCAR2 will be performed with selective agonists (monomethylfumarate, BHB) or antobodies against the HCAR2 commercially available.
This job comes from a partnership with Science Magazine and