Development of methods for the predictions of the protein stability changes upon mutations and pr...

Employer
Università degli Studi di Padova
Location
Italy
Posted
October 02 2017
Position Type
Full Time
Organization Type
Academia

The project consists of three phases. In the first phase we will develop a method to predict the impact of single point mutations on protein stability. This will be carried out starting from previously developed programs, such as INPS and Pro-Maya, then a third new program, based on machine-learning models, will be developed in order to exploit evolutionary information based on the ConSeq program. In the second part of the project, we will develop a method for the prediction of protein interaction sites starting from a single chain. Finally, a dataset of protein mutations related to metabolic diseases will be created to specifically test all the developed methods.



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