Postdoctoral Researcher position (research associate) in Systems Biomedicine (m/f)

Employer
LCSB - Luxembourg Centre for Systems Biomedicine
Location
Luxembourg
Posted
September 29 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

The University of Luxembourg is a multilingual, international research University.


The University of Luxembourg has the following vacancy in the Luxembourg Centre for Systems Biomedicine (LCSB)


Postdoctoral Researcher position (research associate) in Systems Biomedicine (m/f)


  • Ref: R-STR-4024-00-B

  • Fixed-term contract 2 years, (might be extended up to 5 years)

  • Full time (40h/week)

  • Employee status (start date: as soon as possible)

 


Area: Single Cell Omics Analysis of T Regulatory Cells in Barrier Diseases


Please contact for further details:


Dr. Alexander Skupin: alexander.skupin@uni.lu


 


Tasks/Mission:


Background:


T regulatory cells (Tregs) are key players in maintaining tolerance and homeostasis of tissues and the immune system. Treg dysregulation critically contributes to various pathologic conditions such as autoimmune diseases, allergic diseases, infectious diseases, cancer, neurodegenerative diseases and metabolic inflammation. In many of these common chronic diseases, the fine-tuned Treg suppressing system is out of balance. It is essential to understand the precise molecular mechanisms underlying Treg suppressor function both, under homeostatic and disease conditions, in order to re-balance an appropriate Treg function as a major therapeutic strategy for many common chronic diseases.


Project:


The international “Regulatory T cell responses at the crossroads of immune homeostasis and inflammation in the context of barrier diseases” (TregBar) project is an international research project funded by the Luxembourg National Research Fund`s (FNR) bilateral AFR funding instrument. The program will initiate long-term collaborations between the biomedical initiatives of the Luxembourg Institute of Health (Esch-sur-Alzette, Luxembourg) and the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg with the RIKEN Center for Integrative Medical Sciences (IMS) in Yokohama, Japan.


To address the open questions on the balance of the immune system, the project will investigate functional gene regulatory and signaling networks of regulatory Tregs in the context of several barrier diseases by using various murine and human disease models. For this purpose, the collaborative project will combine expertises in basic immunology especially on Tregs, microbiome, single cell analysis, clinical immunology, deep immune phenotyping and computational network analysis.


The successful candidate will therefore work in strong collaboration with different groups and perform single cell transcriptomics analysis using our established DropSeq pipeline and Fluidigm platform to investigate underlying molecular mechanisms of the immune system. The candidate will also spend up to 6 month at the RIKEN institute in Yokohama for additional training on disease models.


Profile:


  • PhD degree in biology, biotechnology, chemistry, physics or in related science

  • experience in molecular biology including transcription analysis and/or immunology

  • experience in microfluidics based approaches would be beneficial but not mendatory

  • delight in travelling

  • critical thinking and collaborative skills

  • excellent English writing and speaking skills are required.

 


Offer:


The Postdoctoral Researcher will be employed at the University of Luxembourg and work in an international and interdisciplinary project on a medical highly relevant system.


Applications (in English) should contain the following documents:


  • A detailed curriculum vitae

  • Cover letter mentioning the reference number

  • List of publications

  • Name and addresses of three referees

 


Please apply ONLINE by 31st October 2017.


The University offers highly competitive salaries and is an equal opportunity employer.


 


Link: http://emea3.mrted.ly/1ld7u



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