Postdoc - Nanobiocatalyst design

Location
Basel
Salary
commensurate with experience
Posted
September 28 2017
Position Type
Full Time
Organization Type
Academia
Job Type
Postdoc

Based in Muttenz near Basel, the FHNW School of Life Sciences is part of Europe’s largest life sciences hub and lies at the heart of pharmaceutical, chemical, environmental and medtech industries.

The Institute of Chemistry and Bioanalytics of the School of Life Sciences (HLS) brings important disciplines in chemistry and life sciences under one roof. In the group of molecular nanotechnology of the HLS, we are developing molecular recognition systems1-3 and biocatalysts4,5 applying core concepts of supramolecular chemistry.

In the frame of a new project funded by the Novartis Research Foundation, we are looking for a highly motivated postdoctoral scientist for developing a novel class of nanobiocatalysts for use in cancer therapy.

Your skills

We look for a highly motivated molecular scientist (chemistry, biochemistry, or related disciplines) with a sound understanding of protein/enzyme chemistry, who enjoys working in a multidisciplinary and multicultural team. Additional experience in synthetic chemistry and analytical techniques (e.g., HPLC-MS, NMR) would be assets. Excellent communications skills in English are mandatory; German is a plus.

Your tasks

You will be responsible of the development of a novel class of engineered nanoparticles in which enzymes of bacterial origin will be encapsulated. The newly designed nanosystems are expected to bypass the human immune system and to allow the activation of specifically designed prodrugs in their therapeutic site.

The work will involve synthesis of silica-based nanoparticles, enzyme kinetics study and high-throughput assay development.

If you have a passion for science and feel up to the challenge, send your application file (including a CV and a cover letter, in pdf format) to :

Prof. Dr. Patrick Shahgaldian, patrick.shahgaldian@fhnw.ch

References

  1. M. Moradi et al. Angew. Chem., Int. Ed. 2017, doi: 10.1002/anie.201703825
  2. N. Moridi et al. Angew. Chem., Int. Ed. 2015, 127, 15013
  3. A. Cumbo et al. Nat. Commun. 2013, 4, 1503
  4. M. R. Correro et al. Angew. Chem., Int. Ed. 2016, 55, 6285
  5. S. Sykora et al., ChemBioChem 2017, 18, 996

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