Molecular Determinants of Mycobacterial Pathogenesis
Postdoctoral/Research Associate Positions in the Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University are available to study molecular mechanisms underlying Mycobacterium tuberculosis, M. haemophilum and M. leprae growth and pathogenesis. One major area of investigation concerns the mechanisms by which these organisms use type VII secretion systems to acquire iron and how these secretion systems modulate pathogenesis in the face of host iron restriction strategies. A second area of interest is the Diaminopimelic acid (DAP) biosynthetic pathway. DAP is a critical component of the mycobacterial cell wall and a stimulator of vertebrate innate immune responses. Using genetic approaches, we have made the surprising observation that it is possible to recover deletion mutants of some presumed essential components of this critical pathway. We are using this information to refine our understanding as to how this pathway may be exploited for therapeutic targeting. For examples of our recent publications, see mBio 2014, mBio 2015 and PNAS 2016. Qualified applicants should have expertise in one or more of the following areas: molecular biology, bacteriology, proteomics or mouse immunology. Prior experience in molecular bacteriology is preferred. These positions offer a competitive salary and great potential for career advancement. The qualified applicant must possess a doctoral degree in a related field of study for Postdoctoral/Research Associate Positions.
JoAnn M. Tufariello, MD-PhD, Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303