Postdoctoral Training Fellow

Location
London (Central), London (Greater) (GB)
Salary
Competitive plus benefits, subject to skills and experience
Posted
September 27 2017
Ref
5585
Position Type
Full Time
Organization Type
Healthcare/Hospital

SUMMARY

An exciting role has come up to be a part of a pioneering biomedical research institute, dedicated to innovation and science. Dr Frickel’s laboratory focuses on elucidating the immune mechanisms targeting the parasite Toxoplasma gondii, as well as deciphering pathways mediated by immune-activated large GTPases. Dr Frickel is seeking a talented and motivated postdoc to further develop this study in human stem cell-derived macrophages and dendritic cells, as a complement to studying these pathways in conventional macrophage cell lines.

PROJECT SCOPE

Infection with the parasite Toxoplasma gondii causes the production of the cytokine gamma interferon (IFN) that in turn leads to the upregulation of a multitude of host defence pathways. Specifically, the lab is interested in ubiquitin-mediated pathogen control (Clough et al, 2016, PLoS Pathogens) and restriction of pathogens by guanylate binding proteins (Johnston et al, 2016, Cellular Microbiology). We are now looking to extend these findings to macrophages as these present the most relevant cell type for Toxoplasma and other infectious agents. We have generated iPSC-derived macrophages as a tool to study IFN-dependent host defence mechanisms. This project will examine how relevant ubiquitin-mediated pathways are to Toxoplasma control in these macrophages and/or how guanylate binding proteins mediate immune defences.

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a brand new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under a single roof in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; to developing emerging talent and exporting it the rest of the UK; to public engagement; and to helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

The closing date for applications is Sunday 29th October 2017 at 23:30.

Please note: all offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.