ILRS_05/2017: Doctoral Researcher (m/f) Influence of the microbiome on Candida colonization and i...

Employer
Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute -
Location
Germany
Posted
September 26 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

The Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute - in cooperation with the Friedrich Schiller University, the University Hospital Jena and the Max Planck Institute for Chemical Ecology are offering an international graduate training programme. The International Leibniz Research School (ILRS Jena) gives doctoral researchers the possibility to prepare for their PhD exam in an ambitious program providing excellent research conditions. We invite applications for a


Doctoral Researcher (m/f)


Influence of the microbiome on Candida colonization and infection

Candida albicans is an opportunistic fungal pathogen that can be found in the majority of healthy humans as a commensal on mucosal membranes, especially in the gut. Risk factors for invasive Candida infections include immunosuppression, but also broad spectrum antibiotic treatment. Furthermore, disturbance of the intestinal microbiota by antibiotic treatment is essential for stable colonisation of adult mice by C. albicans and colonisation resistance is mediated by distinct bacterial taxa. However, the mechanisms by which the microbiota controls fungal growth are only incompletely understood. The aim of this project is to gain novel insights how the microbiota affects C. albicans colonisation, translocation and to which extend it influences the clinical course of disseminated candidiasis.


Based on established murine models, the resistance to intestinal C. albicans colonisation will be determined in genetically identical mice from different breeding facilities that harbour distinct microbiomes. Analysis of the microbiota composition and correlation with colonisation resistance will then be performed to identify components of the microbiota that mediate colonisation resistance. To determine whether physical interactions occur between C. albicans and antagonistic bacteria, imaging will be performed. The effects of selected microbiota on C. albicans colonisation will furthermore be analysed in germfree and/or secondary abiotic mice. Finally, recent evidence suggests that the intestinal microbiota composition also influence susceptibility of infections at other anatomical locations. This hypothesis will be tested by analysing the course of systemic candidiasis in mice with differing microbiota composition with and without prior intestinal exposure to C. albicans.


We expect:


  • a Master's degree (or equivalent allowing you to pursue a PhD degree) in Natural or Life Sciences. Research at ILRS is centred around “Microbial and Biomolecular Interactions”. Candidates about to earn their degree are welcome to apply.

  • experience in standard molecular biology techniques and cell culture; experience in microbiome analysis and/or animal models is an advantage

  • high motivation to join one of the research areas of ILRS

  • creativity and interest in shaping your own cross-disciplinary thesis project

  • an integrative and cooperative personality with enthusiasm for actively participating in our lively community

  • very good communication skills in English, the working language at the ILRS.

We offer:


  • a top-level research environment

  • efficient supervision by a team of advisors

  • a comprehensive mentoring programme

  • courses in state-of-the-art technologies and soft skills

  • strong communication and interaction between the involved institutions

  • Jena - City of Science: innovative business activities, successful scientific centres and a vibrant cultural scene around the famous Friedrich Schiller University

The three-year Doctoral Researcher position is available starting from January 2018. The position will be financially supported according to TV-L (salary agreement for public service employees). HKI is an equal opportunity employer.


Further information:

Prof. Dr. Ilse Jacobsen, PI: ilse.jacobsen@leibniz-hki.de


Dr. Christine Vogler, ILRS Coordinator: ilrs@leibniz-hki.de


The application process is handled exclusively online. Please acquaint yourself with the scientific projects offered on our website. Please note that you can choose up to 3 projects of interest in your application. It is only necessary to fill in the application form for your first preference of projects; the other two projects can be selected in the application form.


Deadline for application: Oct 22, 2017.

Successful applicants will be invited to attend a recruitment meeting in Jena (envisaged date: Dec 14-15, 2017).



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