ILRS_03/2017: Doctoral Researcher (m/f) Mechanisms of bacterial interactions with human pathogeni...

Employer
Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute -
Location
Germany
Posted
September 26 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

The Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute - in cooperation with the Friedrich Schiller University, the University Hospital Jena and the Max Planck Institute for Chemical Ecology are offering an international graduate training programme. The International Leibniz Research School (ILRS Jena) gives doctoral researchers the possibility to prepare for their PhD exam in an ambitious program providing excellent research conditions. We invite applications for a


Doctoral Researcher (m/f)


Mechanisms of bacterial interactions with human pathogenic fungi − the interaction between Aspergillus fumigatus and Pseudomonas aeruginosa

Interactions between bacteria and fungi have major implications for the environment, agriculture and medicine. Little is known about the interactions between medically important bacteria and pathogenic filamentous fungi despite the fact that their interaction can have dramatic effects on the outcome of human disease. In this proposal we focus on the interaction between the pathogenic fungus Aspergillus fumigatus and the pathogenic Gram-negative bacterium Pseudomonas aeruginosa. Both are the most prevalent microbes in cystic fibrosis (CF) patients which underlines the relevance to study their intermicrobial communication processes. Until know, very little is known about the molecular interaction between both microorganisms as well as the impact of a co-infection for pathogenesis of CF. Our preliminary data suggest that unique antimicrobial compounds are produced in A. fumigatusP. aeruginosa co-culture. We will use a combination of genetic, transcriptomic and biochemical approaches to identify novel fungal and bacterial effectors specifically induced during co-cultivation, allowing the opposing organism to inhibit or modulate its partner. Our proposal will also analyze at the molecular level the interaction between strain pairs consisting of a clinical CF isolate and a laboratory control strain of both organisms. In addition to reveal novel mechanisms governing microbial interactions and antibiosis, we expect to identify novel antifungal and antibacterial secondary metabolites (SMs) whose biosyntheses are triggered by the interaction.


We expect:


  • a Master's degree (or equivalent allowing you to pursue a PhD degree) in Natural or Life Sciences. Research at ILRS is centred around “Microbial and Biomolecular Interactions”. Candidates about to earn their degree are welcome to apply.

  • experience in cloning, transformation, genetic engineering, cultivation of microorganisms

  • high motivation to join one of the research areas of ILRS

  • creativity and interest in shaping your own cross-disciplinary thesis project

  • an integrative and cooperative personality with enthusiasm for actively participating in our lively community

  • very good communication skills in English, the working language at the ILRS.

We offer:


  • a top-level research environment

  • efficient supervision by a team of advisors

  • a comprehensive mentoring programme

  • courses in state-of-the-art technologies and soft skills

  • strong communication and interaction between the involved institutions

  • Jena - City of Science: innovative business activities, successful scientific centres and a vibrant cultural scene around the famous Friedrich Schiller University

The three-year Doctoral Researcher position is available starting from January 2018. The position will be financially supported according to TV-L (salary agreement for public service employees). HKI is an equal opportunity employer.


Further information:

Prof. Dr. Axel Brakhage, PI: axel.brakhage@leibniz-hki.de


Dr. Volker Schroeckh, Co-PI: volker.schroeckh@leibniz-hki.de


Dr. Christine Vogler, ILRS Coordinator: ilrs@leibniz-hki.de


The application process is handled exclusively online. Please acquaint yourself with the scientific projects offered on our website. Please note that you can choose up to 3 projects of interest in your application. It is only necessary to fill in the application form for your first preference of projects; the other two projects can be selected in the application form.


Deadline for application: Oct 22, 2017.

Successful applicants will be invited to attend a recruitment meeting in Jena (envisaged date: Dec 14-15, 2017).



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