Postdoctoral Research Fellow, Neuroscience, Hackos Lab, Genentech Research

Location
South San Francisco, California
Salary
DOE
Posted
September 21 2017
Organization Type
Biotech

Postdoctoral Research Fellow, Neuroscience,

Hackos Lab, Genentech Research

 

Join a Team that Lives to Improve Lives

People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen.

The following opportunity exists in our South San Francisco, CA headquarters:

Postdoctoral Research Fellow, Neuroscience, Hackos Lab, Genentech Research

Description

We are seeking a highly motivated postdoctoral research fellow to join the Hackos lab in the neuroscience department at Genentech. Using a diverse set of techniques ranging from detailed structural and pharmacological studies of ion channels to brain and spinal cord neurophysiology and in-vivo behavioral modeling, my lab focuses on the areas of pain and neurodegenerative disease with a particular interest in the role that interneuron circuitry plays in these areas. Our goal is to identify novel drug targets through better understanding of the underlying physiology and pathophysiology of the nervous system.

Selected recent publications form the Hackos lab...

1. A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Wang TM, Brown BM, Deng L, Sellers BD, Lupardus PJ, Wallweber HJA, Gustafson A, Wong E, Volgraf M, Schwarz JB, Hackos DH, Hanson JE. Neuropharmacology. 2017 Jul 15;121:204-218.

2. Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Hackos DH, Lupardus PJ, Grand T, Chen Y, Wang TM, Reynen P, Gustafson A, Wallweber HJ, Volgraf M, Sellers BD, Schwarz JB, Paoletti P, Sheng M, Zhou Q, Hanson JE. Neuron. 2016 Mar 2;89(5):983-99.

3. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Ahuja S, Mukund S, Deng L, Khakh K, Chang E, Ho H, Shriver S, Young C, Lin S, Johnson JP Jr, Wu P, Li J, Coons M, Tam C, Brillantes B, Sampang H, Mortara K, Bowman KK, Clark KR, Estevez A, Xie Z, Verschoof H, Grimwood M, Dehnhardt C, Andrez JC, Focken T, Sutherlin DP, Safina BS, Starovasnik MA, Ortwine DF, Franke Y, Cohen CJ, Hackos DH, Koth CM, Payandeh J. Science. 2015 Dec 18;350(6267).

Information about the postdoctoral program at Genentech can be found at http://www.gene.com/careers/academic-programs/postdocs.

Who You Are

We are looking for a candidate with a PhD degree in physiology, biophysics, neuroscience, or related field and with a background in electrophysiology and/or imaging techniques. A productive track record and at least one first-author publication in a reputable journal are required. Relentless drive and creativity to tackle complex biological questions, enthusiasm to collaborate and learn new technologies, rigorous scientific aptitude, and strong communication and organization skills are essential qualities.

A Job with Benefits Beyond the Benefits

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.