Dissection of the distinct susceptibility of hematopoietic precursors and immune cells to cladribine

Employer
Università di Genova
Location
Italy
Posted
September 21 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

The objective of this project is to assess the effect of cladribine, a drug under evaluation for the treatment of multiple sclerosis, on different selected immature and mature cellular subsets including hematopoietic stem (HSCs) and progenitor cells of the lymphoid and myeloid lineage, T and B cells. This study willfocus on the analysis of the expression of the enzymatic markers responsible for the cladribine cell metabolism through the use of molecular biology techniques. Later we will evaluate the influence of cladribine on HSCs clonogenic and differentiation properties, using cellular biology techniques. This study will allow understanding the different susceptibility of immune cells to cladribine thus improving its clinical use



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