Systemic sclerosis: immune-vascular aspects and clinical correlations.

Employer
Università di Genova
Location
Italy
Posted
September 21 2017
Position Type
Full Time
Organization Type
Academia

Aim of the study will be to evaluate through an in vitro study, the influence of alteration of immune system cells (classically activated/alternatively activated macrophages: M1/M2 ratio) and vascular cells (endothelial circulating cells) on systemic sclerosis (SSc) pathogenesis and phenotypes. The cited parameters will therefore be correlated with clinical parameters and organ involvement, especially with microvascular damage analysed through nailfold videocapillaroscopy.

At least sixty patients affected by SSc according to EULAR/ACR criteria and 30 healthy volunteers (matched for age and sex) will be clinically and instrumentally evaluated



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