Evaluation of prognostic and predictive molecular markers in circulating tumor DNA samples of pat...

Università di Genova
September 21 2017
Position Type
Full Time
Organization Type

In the plasma of patients with breast cancer and colorectal cancer you can detect the presence of circulating tumor DNA (ctDNA), even small amounts of it. The analysis of ctDNA allows, through simple blood tests (liquid biopsy), to identify biomarkers with prognostic and predictive power able to define better the prognosis of patients and to modify the schedule of therapies. From the plasma of serial samples we will extract the ctDNA to search for tumor-specific molecular alterations previously found in the primary tumor. This type of analysis will allow to see the microscopic disease, below the threshold of radiology, in order to monitor the response to therapy and the eventual relapse.

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