Effects of gravitational force changes on the skeleton
Gravitational force changes have important effects on organisms (e.g. skeleton) that adapts itself acting on tissue homeostasis. Our intent is to study those genes that feel gravitational changes like lipocalin-2 that has a pleiotropic effects on the organism. In particular, we will use a transgenic mouse model overexpressing lipocalin-2 already available in our laboratory. Moreover, gene expression analyses will be performed on a 3D cell culture system that reproduces bone microenvironment and that will be maintained in microgravity for a month. Finally hyper gravity effects on the organism will be studied as a possible countermeasure to bone loss observed in different pathologies.
This job comes from a partnership with Science Magazine and