PhD Student in Photo Biocatalysis (Early Stage Researcher) - ESR10

Employer
Graz University of Technology
Location
Austria
Posted
September 20 2017
Discipline
Other
Position Type
Full Time
Organization Type
Academia
Reaction engineering of cyanobacterial photobiotransformations
 
Roles and Responsibilities

The main part of the work (27 months) will be carried out in Graz University of Technology under the supervision of Prof. Robert Kourist in the group of Protein Engineering & Biocatalysis at the Institute of Molecular Biotechnology.


An academic research stay (6 months) will take place at University of Porto (Portugal, with Prof. Paula Tamagnini). 


Additionally, an industrial secondment at a company is foreseen (3 months). The PhD-project is funded for three years and the PhD may start as early as April 2018 (or later).


The PhD degree will be awarded on the basis of successful completion of the research work from two universities (Graz University of Technology, Austria and University of Porto, Portugal) with two PhD certificates (double-degree).


As part of the Marie Skłodowska-Curie Actions, the ESR will be offered additional training and workshop organized by the ITN-EJD Training Program. The ESR is also expected to contribute their time in the dissemination of your project's result through public engagement and other scientific platforms.


The PhD research will focus on:

i) Investigation of cultivation concepts under the guidance of SUB (mixotrophy, inhibitors to minimize CALVIN cycle, light-dark cycles) measurement of product formation, intracellular NADPH levels and quantification of key stress genes by transcriptomics will reveal physiological key factors for cyanobacterial biotransformation;


ii) Using ene-reductase YqjM and Baeyer-Villiger Monooxygenase (CHMO) as model system, introduce these enzymes into the optimized chassis system at University of Porto for control of enzyme levels and electron flow; 


iii) Analyse key parameter for up-scale, up-scale to 5L and then 25L, development of downstream-processing, and commercialization with the industry partner.


 


 



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