Postdoctoral position in NMR-based Structural Biology

Employer
University of Gothenburg
Location
Sweden
Posted
September 18 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

Diary id: PAR 2017/1080


Employment level: Time limited employment (temporary)


Location: Department of Chemistry and Molecular Biology



Apply by: 2017-10-15




Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.





The group of Björn Burmann uses state of the art NMR-spectroscopy to study large molecular complexes underlying basic cellular functions at the atomic level in combination with other structural biology methods and biophysical characterization. Our group will use E.coli based expression for specific isotope-labeling suited to study large proteins and their respective molecular complexes playing an integral role for transcription-coupled repair, whose malfunction within these essential repair machineries leads to cell death and diseases like skin cancer in the related eukaryotic systems. Results of previous studies into transcription regulation at the atomic level have been published in top journals (Burmann et al. Science 2010/Burmann et al. Cell 2012). More details on our research can be found at: (www.wcmtm.gu.se/research-groups/burmann).


Subject area


Structural Biology, Biophysics, and Biochemistry


Subject area description


Structural characterization and biophysical analysis of transcription associated processes


Job assignments


Information about the job assignments: The PostDoc project aim at advancing the molecular understanding of the function and regulation of transcription-coupled DNA-repair at the atomic level by advanced NMR-spectroscopy. Malfunction of this important DNA repair machinery leads to the accumulation of DNA errors in the respective cells, which subsequently can provide the foundation for cell death in bacteria. Specifically, you will study (1) the molecular mechanisms by which important repair initiation factors are recruited to the RNA-polymerase (2) how these proteins recognize the damaged DNA-site, and (3) how these proteins subsequently recruit the whole DNA repair machinery. To achieve this goal you will use a plethora of techniques ranging from basic biochemistry to advanced structural biology methods (not restricted to NMR-spectroscopy only, as it is planned to also apply X-Ray crystallography or cryo-electron microscopy whenever indicated by our data) and biophysical characterization. Methods in microbiology, molecular biology, bioinformatics and biochemistry will also be used. We are looking for a colleague, that is highly motivated, scientifically independent and creative, and capable of contributing to a team environment.


Eligibility


To qualify as a postdoctoral fellow, the applicant must have completed a Swedish doctoral degree or must have a foreign degree corresponding to a Swedish doctoral degree. Preference will be given to candidates who have been awarded the degree no more than three years before the application deadline and who have not held a post-doc position within the same or similar subject area at the University of Gothenburg for more than one year. Applicants with a degree obtained earlier than the stipulated three years may be preferred if special reasons exists. Special reasons in this context include, but are not limited to, leave due to illness and parental leave. A relevant background in Molecular Biology, Biochemistry, Biophysics, Structural Biology or related fields is expected.


Assessment


Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance. The successful candidate should have a strong background in biochemistry, biophysics, and/or NMR spectroscopy. Previous work with nucleic acids and nucleic acid binding proteins, e.g. expression and purification and/or functional characterization, will be considered an advantage. Authorship in high impact journals such as Angewandte Chemie or Nucleic Acids Research is favorable.


Employment


Type of employment: Fixed-term employment, 2 years


Extent: 100 %


Location: Department of Chemistry and Molecular Biology, Gothenburg


First day of employment: 01.11.2017 or to be agreed


Appointment procedure


Please apply online


The application shall include:


Cover letter with an explanation of why you apply for the position


CV including scientific publications


Copy of exam certificate


Two referees (name, telephone no, relation)


For further information:


- Regarding the position please contact


Björn Burmann, Ass. Professor, +46(0)31 786 3923 bjorn.marcus.burmann@gu.se


Göran Hilmersson, Head of Department +46 (0) 31-786 9022, hilmers@chem.gu.se 


Regarding the appointment procedure, please contact Ann Svensson, Human Resources Officer +46 (0) 31-786 2558, ann.svensson@cmb.gu.se


Unions


Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives


How to apply


In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.


The application is to be written in English.


Closing date: 15th October 2017


 


The University of Gothenburg promotes equal opportunities, equality and diversity.


Salary is determined on an individual basis.


Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.




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