Probing mechanisms of delivery of pharmaceuticals from nano-confined environments (KHIMYAKY1_U18SF)

Employer
University of East Anglia
Location
Other
Posted
September 15 2017
Position Type
Full Time
Organization Type
Academia

Molecular level control of self-assembly of pharmaceuticals at different length scales is a significant challenge both in industrial and academic research. Confinement of pharmaceuticals in porous matrices can lead to stabilisation of unusual forms which can be beneficial for their delivery and improved bioavailability. Although such advantages have been illustrated on some examples, an in-depth molecular level of organisation and intermolecular interactions in such systems is needed to extend such approaches to new classes of pharmaceuticals with often reduced solubility or complex polymorphic behaviour. This project will aim to build correlations between the strength of intermolecular and host-guest interactions at different levels and dissolution profiles of nano-confined pharmaceutical materials. Probing such systems at various lengths scales (using NMR spectroscopy and other methods) will enable us to generate a formulation strategy towards novel nanoporous drug delivery systems with significantly improved level of control over their dissolution kinetics.


This PhD project is an excellent opportunity for a candidate to increase their expertise in a highly challenging area of research with considerable industrial relevance and potential to make a significant impact on the development of novel pharmaceutical materials. Through completing the project you will acquire knowledge of a wide range of computational and experimental methods (including different aspects of NMR spectroscopy) essential in highly competitive academic or industrial environments.


The PhD project is available to graduates in the fields of chemistry, materials science, physics or pharmacy with a degree classification of 2.1 or above (of its equivalent). For further information please contact Professor Yaroslav Khimyak (y.khimyak@uea.ac.uk) as soon as possible.


Funding notes


This PhD project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources.  Details of tuition fees can be found at http://www.uea.ac.uk/study/postgraduate/research-degrees/fees-and-funding.


A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research.  The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.



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