Engineering smart drug delivery systems using thermal and electrohydrodynamic nanofabrication (QI...
Controlled and targeted drug delivery can significantly benefit the patient adherence to treatment and improve the overall therapeutic outcomes. The majority of controlled release and targeted drug products used in clinic are matrix based systems and rely on the response of the materials in the formulation to control the rate and site of drug release. The lack of a complex 3D architecture at the micro and nano scale of current products is largely a result of the limitations of conventional manufacturing methods. Thermal and electrohydrodynamic processes including FDM 3D printing, electrospinning and electrospraying have been widely used in other industries such as prototype production and semiconductor production. With the emergence of these micro and nanofabrication methods adapted for pharmaceutical manufacturing, a fuller understanding of how micro and nanostructures of formulations can control the delivery of drugs is crucial for realising the full potential of these novel fabrication methods [i-iii]. This PhD project will explore the use of the interior and surface architectures of solid formulations prepared by the novel hybrid fabrication method of FDM 3D printing and electrohydrodynamic method to regulate the release of therapeutic agents. The project will involve both creating formulations with complex micro and nanostructures via novel fabrication methods along with structural characterisation and drug release modelling. This project offers an excellent opportunity to interact with a multi-disciplinary network of our existing collaborators working in the field of pharmaceutical research and product development. The outcome of the project will provide valuable contribution to the field of controlled drug delivery via spatial microstructure design.
This PhD project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at http://www.uea.ac.uk/study/postgraduate/research-degrees/fees-and-funding.
A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.
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