UCD Post-doctoral Research Fellow Level 1 or UCD Post-doctoral Research Fellow Level 2, UCD Schoo...

Employer
UCD
Location
Europe
Posted
September 12 2017
Position Type
Full Time
Organization Type
Academia

Applications are invited for a temporary post as UCD Post-doctoral Research Fellow Level 1 or UCD Post-doctoral Research Fellow Level 2


Project: An Investigation of the mechanisms linking C5orf30 with tissue damage in RA


The aetiology of rheumatoid arthritis (RA) is multifactorial involving both genetic and environmental influences. Genome wide association studies have identified more than 100 susceptibility loci including a variant, rs26232, in the 1st intron of C5orf30. We have also described an allele dose association of this variant with severity of x-ray damage of the hands and feet joints. The gene encodes a protein of 206 amino acids that is highly expressed by RA synovial fibroblasts and macrophages. This research project will investigate the mechanisms underlying the genetic link of rs26232 with tissue damage and investigate the interactome of C5orf30 in synovial fibroblasts. Our objectives are to ascertain if rs26232 genotype is; (1) correlated with RASF phenotypic characteristics in vitro including invasiveness, migration and gene expression profiles, (2) differential nuclear protein binding, (3) associated with 3' untranslated variants of C5orf30 and with differential intracellular localization. We will also identify the interactome of C5orf30 in synovial fibroblasts and determine key interaction domains. These experiments will give important novel information on the biology of C5orf30 in mediating tissue damage in RA.


See Job Description for further details.


Salary: €34,975 - €38,063 per annum


Or


Salary: €39,155 per annum


This position may be appointed at either UCD Post Doctoral Research Fellow Level 1 or Level 2 depending on the relevant qualifications and experience of the successful candidate


Closing date: 17.00hrs (Local Irish Time) on Wednesday, 20 September 2017


Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17:00hrs GMT on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.


Prior to application, further information (including application procedure) should be obtained from the UCD Job Vacancies website: http://www.ucd.ie/hr/jobvacancies.


UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.



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