BIOMARKERS OF OXIDATIVE STRESS, ENDOTHELIAL DYSFUNCTION AND CARDIOVASCULAR RISK IN ULTRAMARATHON ...

Employer
Università degli Studi di Urbino Carlo Bo - Dip. di Scienze Biomolecolari (DISB) - Urbino
Location
Italy
Posted
September 12 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

The 24-hour ultramarathon race is characterized by an aerobic overload that can lead to oxidative stress, a chemical imbalance involved in endothelial dysfunction, atherosclerosis, and increased risk of cardiovascular diseases. In order to highlight and possibly prevent such critical issues, the present research aims to investigate in professional athletes participating to a 24-hour ultramarathon competition, the serum markers of oxidative stress as well as circulating markers of altered endothelial/cardiac function. The research also includes ex vivo experiments performed on endothelial cell lines treated with sera taken from ultramarathon athletes. This last approach will be performed in order to better understand the cellular mechanisms underlying the endothelial dysfunction induced by such extreme sports events.



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