Postdoctoral Fellow in structure-based ligand design for riboswitches

Employer
University of Bergen
Location
Norway
Posted
September 11 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

At the Department of Biomedicine in the group of Professor Ruth Brenk (http://www.uib.no/en/rg/brenk ) a full-time (100 %) position as Postdoctoral Fellow is available for a period of 3 years. The position is part of the project “Chartering chemical space of riboswitch ligands - toward future antibiotics” financed by the FRIMEDBIO programme of The Research Council of Norway.


 


 


Project


The main focus of the project will be structure-based ligand design for the discovery of riboswitch ligands. Riboswitches are regulatory domains within messenger RNA in bacteria and are considered as promising targets for the development of new antibiotics. The work will be conducted in close collaboration with the medicinal chemistry group at the University of Bergen (http://www.uib.no/en/persons/Bengt.Erik.Haug). Further, we have collaborators in Germany and Canada.


 


Postdoctoral Fellow


The main objectives for the position are


  • to design promising riboswitch ligands based on available crystal structures

  • to develop an assay suitable for fragment screening against riboswitches using either surface plasmone resonance (SPR) or biolayer interferometry (BLI)

  • to conduct fragment screenings

  • to determine the binding affinities of test compounds

  • to determine the crystal structures of RNA-ligand complexes

  • to supervise master- and PhD students

For further information please contact Ruth Brenk, e-mail: ruth.brenk@uib.no, phone: +47 55 58 60 70.


 


Qualifications and qualities


  • The candidate must hold a PhD-degree within the field of molecular biology, pharmacy, biochemistry, medicinal chemistry or a related discipline or have submitted their doctoral dissertation within the specified field for evaluation within the closing date of the application. It is a condition for appointment that the dissertation is approved.

  • The candidate must have documented experience in at least one of the following areas:
    • Structure-based ligand design

    • X-ray crystallography of macromolecules

    • SPR or BLI

    • In vitro transcription of RNA

    • Fragment screening


  • Experience in several of the listed areas will be advantageous.

  • Excellent communication skills and fluency in both written and spoken English are required.

  • The candidate must demonstrate a strong commitment for scientific research.

  • Personal skills will be emphasized. The candidate must be able to work independently and interactively in a team setting, be motivated and responsible, and also have a great work capacity and enthusiasm for research.

  • Prior publication record will be of importance.

The candidate is expected to spend several months in the group of our collaborators abroad.


 


We can offer


  • A good and challenging work environment in research front of RNA-ligand interactions.

  • Salary level 57 (code 1352/pay framework 24.1) at present NOK 486 100 gross p.a. Further promotion will be after service seniority in the position. A pension contribute of 2 % will be deducted and deposited to the state pension scheme.

  • A good pension scheme in the Norwegian Public Service Pension Fund

  • Inclusive workplace (IW)

  • Good welfare benefits

For more information regarding what the University of Bergen can offer its employees please visit: http://www.uib.no/en/poa/74243/what-can-university-bergen-offer-its-employees


 


For further information about the recruitment process, click here


For more information and how to apply



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