From Single-Cell to Multi-Cells Information Systems Analysis
This project embraces the single-cell revolution allowing the analysis of thousands of genes, mRNAs and proteins, within a single cell, for hundreds of cells in parallel. The number of variables, their heterogeneity and the complexity of biological systems, pose a number of methodological challenges that require completely new theoretical and applicative approaches.
This project aims at addressing the problem using data from an in-vitro artificial organ produced from induced pluripotent stem cells, considering it as a complex multi-agent systems made of multiple types of cells, spatially and temporally organized and able to communicate and interact with each other and to orchestrate self-assembly and response to stimuli.
This job comes from a partnership with Science Magazine and