Signalling compartmentalization and vesicle Trafficking at the Phagocytic Synapses
Investigate the role of mitochondrial dynamics in the activation of macrophages in pathological conditions.
The assigner will investigate the role of purinergic signals in phagocytosis, using fluorescence microscopy, time-lapse imaging in vital slices, cytofluorometry, biochemistry. The aim of STEPS is to understand the molecular interactions leading to the formation of a functional phagocytic synapse and macrophage activation, two crucial events in inflammatory responses and immunity. Specifically, we will focus on three distinct aspects linking immunology to cell biology: the formation of dynamic platforms for pathogen recognitions; signaling compartimentalization at the plasma membrane; vesicle and organelle trafficking. These mechanisms will be analized in both physiological and phatological contest
This job comes from a partnership with Science Magazine and