Signalling compartmentalization and vesicle Trafficking at the Phagocytic Synapses

Employer
Università degli Studi di Padova - Dipartimento di Scienze Biomediche
Location
Italy
Posted
September 07 2017
Position Type
Full Time
Organization Type
Academia

Investigate the role of mitochondrial dynamics in the activation of macrophages in pathological conditions.

The assigner will investigate the role of purinergic signals in phagocytosis, using fluorescence microscopy, time-lapse imaging in vital slices, cytofluorometry, biochemistry. The aim of STEPS is to understand the molecular interactions leading to the formation of a functional phagocytic synapse and macrophage activation, two crucial events in inflammatory responses and immunity. Specifically, we will focus on three distinct aspects linking immunology to cell biology: the formation of dynamic platforms for pathogen recognitions; signaling compartimentalization at the plasma membrane; vesicle and organelle trafficking. These mechanisms will be analized in both physiological and phatological contest



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