Synthesis of new organic and organometallic compounds containing (R)-9-hydroxystearic acid or its...

Employer
ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI CHIMICA INDUSTRIALE "TOSO MONTANARI"
Location
Italy
Posted
September 05 2017
Position Type
Full Time
Organization Type
Academia

The synthesis of new molecules with selective activity against tumor cells and which can overcome the problem of drug resistance is of increasing interest. (R)-9-Hydroxystearic acid (9-HSA) is a compound with antineoplastic activity for inhibition of histone deacetylases. The likeness of a 9-HSA part with Vorinostat suggested the synthesis of new 9-HSA derivatives containing the C1-C9-chain linked to heterocycles. 9-HSA will also be esterified with molecules exhibiting antitumor activity. In addition, some Ruthenium complexes have antitumor activity with the benefit of lower toxicity than cis-platinum. Previous studies on the reaction of the Ruthenium complex [(PPh3)3Ru (CO) (H)2] with acetic acid thymine as a nucleobase model suggested the synthesis of similar complexes containing 9-HSA to be tested as an alternative to platinum derivatives. The biological activity of the new compounds will be evaluated by research teams that collaborate with the proposers.



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