Positions for PhD Students and Postdocs: Chromosome structure and transcriptional regulation

Employer
Friedrich Miescher Institute for Biomedical Research
Location
Switzerland
Posted
September 04 2017
Discipline
Other
Position Type
Full Time
Organization Type
Academia

Positions for PhD students and postdocs funded by an ERC Starting Grant are available in the group of Luca Giorgetti at the Friedrich Miescher Institute for Biomedical Research (FMI) in Basel. Our lab studies the interplay between genome architecture and gene expression in mammalian cells, using an interdisciplinary approach combining methods from molecular biology, imaging, genomics and physical modelling. See: Zhan et al. Genome Research 27:479-490 (2017); Giorgetti et al. Nature, 535:575-579 (2016); Giorgetti et al. Cell 157: 950-63 (2014); Giorgetti et al. Molecular Cell 37: 418-28 (2010)


Understanding chromosome structure, including how it varies from cell to cell and in time, is fundamental to determine how stochastic and dynamic regulatory interactions between genes and their cis-regulatory elements such as enhancers are translated into robust transcriptional outputs, and result in accurate gene expression. To address these questions, successful candidates will apply existing techniques and develop innovative methods for imaging RNA and DNA, studying chromosome structure in single cells and in time, and analysing quantitative datasets.


We are looking for highly motivated, intellectually curious individuals that enjoy challenging projects aimed at addressing fundamental biological questions, and benefit from cross-disciplinary interactions. We encourage applications from candidates with either an experimental or a computational background. Familiarity with any of the following topics will be considered an advantage but are not mandatory: gene regulation/chromatin biology, live-cell microscopy, or physical modelling. Our lab provides an interdisciplinary environment where communication and organization, as well as the ability to work independently in the context of a larger team, are essential. These skills will be therefore highly valued. A very competitive salary and access to the cutting-edge FMI research facilities will be provided.


The FMI is a world-class research institute in basic biomedical science affiliated with the University of Basel and the Novartis Institutes for BioMedical Research. Basel is a vibrant city offering an outstanding scientific environment as well as excellent opportunities for cultural and outdoor activities. It is located in the centre of Europe with easy access to other European cities such as Zurich, Milan or Paris.


Applications for postdoctoral positions should be submitted electronically at www.fmi.ch/opening and include a motivation letter, CV and names and email addresses of two referees.


Candidates for PhD studentships should apply through our International PhD Program (http://www.fmi.ch/Training/PhD/). Please note that there are two application deadlines per year (usually in May & Nov). Interested candidates who wish to apply outside the period of these open calls should contact Luca Giorgetti directly by email.


For further information, please contact: Luca Giorgetti, luca.giorgetti@fmi.ch


www.fmi.ch/giorgetti.l
www.fmi.ch



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