EVALUATION OF THE GENOTOXICITY AND THE MUTAGENICITY OF SYNTHETIC ISOTHIOCYANATES DIRECTED TO THE ...
A recent strategy to improve the pharmacological and toxicological profile of antiblastic therapy is to target the drug to the endoplasmic reticulum (ER). Persistent and generalized stress at the ER level could initiate the apoptosis or cell death process. It is well known the chemopreventive and antitumor activities of the isothiocyanates, which are produced by the enzymatic conversion of the glucosinolates present in Brassica vegetables.
This project aims to study the cytotoxicity, the genotoxicity and the mutagenicity of synthetic compounds characterized by an isothiocyanate group associated with a selectively directed ER carrier. Jurkat cells, a T-lymphoblastoid cell line, and untransformed peripheral blood lymphocytes will be employed in this project. This experimental approach will allow to evaluate the potential selectivity of action of these compounds and to delineate their toxicological profile.
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