Cryo-EM, Associate Principal Scientist Job

Kenilworth, NJ, US
September 01 2017
Organization Type
Cryo-EM, Associate Principal Scientist-CHE005524


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

This position within the Biochemical Engineering & Structure department at Merck Research Laboratories (Kenilworth NJ USA) will support drug discovery through the use of atomic resolution single particle cryo-EM to determine the structure of therapeutically important targets. The successful candidate will join our growing cryo-EM team and be responsible for all aspects of the single particle cryo-EM process, from sample preparation and data collection through 3-D reconstruction and will work in collaboration with medicinal and computational chemists. The successful candidate will work closely with molecular biologists, biochemists and biophysicists for sample optimization.

Productive and collaborative interactions with other members of the global, cross-functional department are required. There is an expectation for periodic travel to other locations. Cooperative and collaborative use of internal expertise and resources will be essential to success. The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at national or international meetings.

Consistently cited as a great place to work, Merck employs talented people who discover, develop, manufacture, and market a wide range of vaccines and medicines to address unmet medical needs. Each of us is joined by an extraordinary sense of purpose — bringing Merck’s finest achievements to people worldwide. The Merck Kenilworth campus is located within commuting distance from NYC. This close proximity allows for close interactions with the quickly expanding high resolution single particle cryo-EM community as well as the structural biology field at large, giving easy access to the latest developments in the field.



- A Ph.D.


- At least 6 years postdoctoral training in cryo-EM.
- Demonstrated experience in a broad range of activities for atomic resolution single particle cryo-EM, including sample preparation, data collection, image processing & 3-D reconstruction.
- Excellent communication skills (written, presentation, and oral) that enhance team-based progress is required. Application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management is required.
- Demonstrated potential to develop project management skills and identify/develop new areas of scientific expertise in cryo-EM.
- Ability to work effectively and flexibly within timelines.
- Ability to prepare peer-reviewed publications.


- Experience with the cryo-EM microscope setup, operations and maintenance
- Experience with hardware and software related to EM methods or experience with other electron microscopy techniques (for example SEM or tomography)
- Experience with biophysical and functional characterization methods (e.g. SPR, thermal shift and calorimetric assays) to guide construct design and optimization of properties for successful structural outcomes

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.

If you need an accommodation for the application process please email us at

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Job: Chemistry

Job Title:Assoc Prin. Scientist, Chemistry

Primary Location: NA-US-NJ-Kenilworth

Employee Status: Regular

Number of Openings: 1

Hazardous Materials: Biochemistry and chemistry lab reagents

Company Trade Name:Merck

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