Doctoral candidate in Biochemistry

Employer
University of Turku, Department of Biochemistry
Location
Finland
Posted
August 29 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

The University of Turku is a world-class multidisciplinary research university which offers interesting challenges and a unique vantage point to national and international research and education.


AN OPEN POSITION OFFERED AS A DOCTORAL CANDIDATE / PROJECT RESEARCHER AT THE UNIVERSITY OF TURKU, DEPARTMENT OF BIOCHEMISTRY


The doctoral candidate joins a newly established research group of Dr. Anssi Malinen (http://www.utu.fi/fi/yksikot/sci/yksikot/biokemia/tutkimus/bk/ret/Sivut/...). The focal point of the lab's current research is RNA polymerase I (Pol I) that is specialized to produce ribosomal RNA. We aim to elucidate, on the level of detailed molecular mechanisms, the function and regulation of Pol I. We specifically wish to uncover the identity, sequence and quantitative parameters of the molecular events taking place at the beginning of RNA polymerase l mediated production of ribosomal RNA. The research approach depends on sophisticated biochemical and biophysical tools that we develop to monitor the function of purified Pol I proteins in real-time. Our primary model system is isolated from yeast but the studies are expected to expand also towards the human system. Importantly, dysregulation of Pol I activity is linked to the etiology of many human cancers and hereditary disorders. The molecular mechanisms that we will uncover thus pave the way for new Pol I targeting cancer drugs.


The group and doctoral position is funded by a prestigious grant from Academy of Finland. Ph.D. studies in Finland should be completed within 4 years and require publication of original research articles as well as some formal course work. The project facilitates versatile training in state-of-the-art molecular biosciences. Our research approach is experimental major techniques including nucleic acids molecular biology, cell strain engineering (yeast and human cells), protein expression and purification, enzyme kinetics, single-molecule fluorescence microscopy, bioinformatics and structural biology (modeling and cryo-EM).



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