Study of the role of the GBA-mediated lysosomal impairment in Parkinson's disease

Employer
Humanitas University
Location
Italy
Posted
August 29 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

the project is aimed to study the mechanisms explaining how the progressive lysosomal impairment triggered by the glucosylceramide (GlcCer)/Syn accumulation, caused by defective GCase activity, determines the outcome of a neurodegeneration process in GBA-dependent PD. In particular, we will pursue three main objectives: i) elucidate the molecular mechanisms involved in the onset of cell damage occurring in GBA-PD; ii) in-depth characterize the RNA-based regulatory network including the GBA gene, its pseudogene GBAP1, and the microRNA miR-22, and verify its dysregulation in PD; iii) analyze the genetic contribution of lysosomal genes (other than GBA) in PD pathogenesis.



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