PhD-student Physics or Related Field of Study
Hyperthermia is the application of elevated temperatures (41-45°C) to tumour tissue to sensitize chemotherapy and radiotherapy and is applied in combination with chemotherapy or radiotherapy to improve tumour control. During Hyperthermic Intraperitoneal Chemotherapy (HIPEC) a chemotherapy solution heated to ~43°C is circulated through the peritoneum for 30 minutes up to one or more hours. Surgery followed by HIPEC is used to suppress macroscopic as well as microscopic peritoneal metastases of cancers of different origins.
The research project “Development of patient specific treatment planning to enhance and optimize clinical effectiveness of hyperthermic intraperitoneal chemotherapy in colorectal cancer patients” is supported by a grant of the Dutch Cancer Society KWF and aims to optimize the clinical effectiveness of the HIPEC procedure by developing patient specific HIPEC planning software to predict, control and optimize the flow, temperature and chemo distribution in the peritoneum during a HIPEC procedure. This planning software will be developed specifically for patients treated with oxaliplatin HIPEC for peritoneal metastases of colorectal cancer origin and will be validated by simulations and in an animal model. A PhD student with a background in physics is requested. This student will work at the department of Radiation Oncology of the Academic Medical Center of the University of Amsterdam and will develop sophisticated mathematical models integrating data on flow, temperature, chemotherapy concentration, temperature dependence of the effect of chemotherapy, temperature dependence of the penetration of chemotherapy into tissue using the data provided by another PhD student with a background in biology already working on the project. This software will first be evaluated in an animal model and then used to optimize the HIPEC procedure in patients to achieve an optimal temperature and chemotherapy distribution, resulting in better clinical outcome.
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