PhD Student- Patient profiling, samples and biopsy tools for OsteoArthritic patients
The aim of this PhD position is twofold; the first aim is to develop a tool that ensures a standard quality and quantity of tissue and fluids collected from patients with different grades of OsteoArthritis (OA) by the department of Orthopaedic Surgery, the second aim is to examine and search for biomarkers which help to further unravel different phenotypes and disease progression. In the future we aim to identify the most appropriate treatment by phenotype or, where relevant, fully personalized. Patient classification will be achieved by making a unique combination between known prognostic factors and new biomarkers (metabolites, lipids, proteins). These biomarkers will be determined by collecting and analyzing tissue samples of patients during planned surgical treatments using latest cell and tissue analysis techniques in collaboration with M4I Biovolt B.V., and Zimmer-Biomet. This means we are looking for a PhD student who has some experience in fundamental (OA) research and mass spectrometry, set up a database in which different types of data come together, obtain permission from the METC, visiting the operating room, and be able to work with tissue/cell analysis techniques. Before and parallel to building this unique database, a set of requirements for a point-of-care device that can determine the relevant biomarkers based on the experience in tissue collection with existing analytical techniques will be established. You will work closely with a postdoc who will have complementary expertise to conduct this research.
This research is done within a consortium consisting of the MUMC+ Orthopaedics Department, 5 University Medical Centers, 12 companies and various foundations. The project is funded from Applied and Applied Sciences within the perspective research program entitled 'William Hunter Revisited: Activating intrinsic cartilage repair to restore joint homeostasis' to make a major step in regenerating cartilage.
This job comes from a partnership with Science Magazine and