Efficacy and mecanisms of action of physical exercise and of perceptual learning in enhancing adu...
The reduction in cortical plasticity characterizing critical period closure is one of the major obstacles hampering recovery from deficits due to defective neurodevelopment. A classical example is lack of recovery from amblyopia in past critical period subjects.
In animal models of amblyopia we have recently shown that a complete recovery of visual acuity can be obtained with the use of treatments easily transferable to humans, such as physical exercise (PE) and visual perceptual learning (VPL). The effects of PE and VPL in promoting recovery of binocular vision in animal models of amblyoia are still unknown, and so are the mechanism underlying the beneficial effects of these protocols.
We aim at:
1) assessing PE and VPL efficacy in promoting recovery of binocular vision in adult amblyopic rats
2) dissecting the mechanisms at the basis of the induction and maintenance of visual recovery, and in particular dissecting which GABAergic inhibitory interneuron subtypes are involved
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