Research Scientist I

Gilead Sciences, Inc.
Foster City, California
August 14 2017
Organization Type

Research Scientist I


Specific Responsibilities:

Gilead seeks a highly talented and motivated research scientist to join and help drive ongoing and new efforts in the discovery and development of novel therapies for the treatment of chronic fibrotic and metabolic diseases including non-alcoholic steatohepatitis (NASH). This research position is within a highly collaborative department with an established group focused on fibrotic diseases. The successful candidate will participate in discovery and translational research efforts aimed at identifying and characterizing novel therapeutic targets, investigating mechanism of action of therapeutics, and defining optimal drug combinations.


Essential Duties and Job Responsibilities:

The successful candidate will work in a highly collaborative, project team-based research structure to lead or support biological investigations of new and established projects within Research. The candidate will be expected to significantly participate in and lead discovery efforts for fibrosis targets including defining and implementing critical path studies needed to support hypothesis-based research and will manage these activities in our group across multiple project teams. The successful candidate will also oversee and/or directly manage new and established external collaborations. The successful candidate will participate as an engaged member of a highly interactive biology department.


Knowledge, Experience and Skills:

Applicants must have a PhD or equivalent degree and at least 3 to 4 years of relevant post graduate experience inclusive of either post-doctoral work or employment in the pharmaceutical industry. The candidate will have a strong track record of scientific accomplishments, demonstrated by peer-reviewed scientific publications in high impact journals. The candidate will have experience in using and understanding modern cell biology and pharmacology techniques to enable research in this area. This should include an understanding of metabolism and metabolic dysfunction in NASH and type 2 diabetes, evaluation of hepatic fibrosis and intracellular signaling networks, and the use of both in vitro cell-based assays and pre-clinical models to interrogate disease pathways and drug targets. The candidate will have significant experience in using state of the art molecular techniques including methods to evaluate signaling networks (western blot, ELISA, proteomics), gene expression analysis (RT-PCR, Nanostring, RNA-seq), and will have a working knowledge of functional genomics. The candidate should also have demonstrable experience in cell-based assay development, including the use of hepatocyte cell culture and assessment of mitochondrial function/dysfunction. A working knowledge or experience with the design and execution of in vivo pharmacology studies is a plus. Preference will be given to candidates with direct experience in glucose and lipid metabolism and the role of mitochondrial dysfunction in metabolic disease.

This individual will have demonstrable skills and experience in hypothesis-driven biological research. Strong communications skills required, with a demonstrated ability to communicate and scientifically engage individuals across a large breadth of levels and translate ideas and data into concise written communications.


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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact for assistance.